T-cell anergy
Identifieur interne : 000310 ( Istex/Curation ); précédent : 000309; suivant : 000311T-cell anergy
Auteurs : Christine M. Seroogy [États-Unis] ; C. Garrison Fathman [États-Unis]Source :
- Immunologic Research [ 0257-277X ] ; 2003-12-01.
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Abstract
Abstract: For many decades, anergy has been used as a descriptive term to describe a state of antigen-specific unresponsiveness. A better understanding of this phenotype was revealed in the 1980s using in vitro model systems. These model systems demonstrated that protein synthesis and mobilization of Ca2+ was required leading to the pursuit of a novel gene(s) that would be unique to the anergy phenotype. Several putative “anergy factors” have been suggested. In this review, we provide an overview of the anergy phenotype and proposed anergy-related genes. To date, no single gene has been described that would completely fulfill the criteria of an “anergy factor”. We review work from our laboratory describing a novel gene that we have termed Gene Related to Anergy In Lymphocytes (GRAIL) that is upregulated in T cells anergized in vitro and in vivo and, following transduction into T cells, reiterates the anergy phenotype.
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DOI: 10.1385/IR:28:3:255
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">T-cell anergy</title><author><name sortKey="Seroogy, Christine M" sort="Seroogy, Christine M" uniqKey="Seroogy C" first="Christine M." last="Seroogy">Christine M. Seroogy</name><affiliation wicri:level="2"><mods:affiliation>Department of Pediatrics, University of Wisconsin, Madison, WI</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Pediatrics, University of Wisconsin, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Fathman, C Garrison" sort="Fathman, C Garrison" uniqKey="Fathman C" first="C. Garrison" last="Fathman">C. Garrison Fathman</name><affiliation wicri:level="2"><mods:affiliation>Department of Medicine, Division of Immunology and Rheumatology, 300 Pasteur Dr., CCSR Building Room 2225, 94305-5166, Stanford, CA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Medicine, Division of Immunology and Rheumatology, 300 Pasteur Dr., CCSR Building Room 2225, 94305-5166, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: cfathman@stanford.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1AA10F315BBEB5221F2AFE1EA346C537FD3AF41C</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1385/IR:28:3:255</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-CN4ZMM4H-4/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000310</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000310</idno><idno type="wicri:Area/Istex/Curation">000310</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">T-cell anergy</title><author><name sortKey="Seroogy, Christine M" sort="Seroogy, Christine M" uniqKey="Seroogy C" first="Christine M." last="Seroogy">Christine M. Seroogy</name><affiliation wicri:level="2"><mods:affiliation>Department of Pediatrics, University of Wisconsin, Madison, WI</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Pediatrics, University of Wisconsin, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Fathman, C Garrison" sort="Fathman, C Garrison" uniqKey="Fathman C" first="C. Garrison" last="Fathman">C. Garrison Fathman</name><affiliation wicri:level="2"><mods:affiliation>Department of Medicine, Division of Immunology and Rheumatology, 300 Pasteur Dr., CCSR Building Room 2225, 94305-5166, Stanford, CA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Medicine, Division of Immunology and Rheumatology, 300 Pasteur Dr., CCSR Building Room 2225, 94305-5166, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: cfathman@stanford.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Immunologic Research</title><title level="j" type="abbrev">Immunol Res</title><idno type="ISSN">0257-277X</idno><idno type="eISSN">1559-0755</idno><imprint><publisher>Humana Press</publisher><pubPlace>Totowa</pubPlace><date type="published" when="2003-12-01">2003-12-01</date><biblScope unit="volume">28</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="255">255</biblScope><biblScope unit="page" to="264">264</biblScope></imprint><idno type="ISSN">0257-277X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0257-277X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anergy</term><term>Soluble peptide</term><term>Superantigens</term><term>T lymphocytes</term><term>Tolerance</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: For many decades, anergy has been used as a descriptive term to describe a state of antigen-specific unresponsiveness. A better understanding of this phenotype was revealed in the 1980s using in vitro model systems. These model systems demonstrated that protein synthesis and mobilization of Ca2+ was required leading to the pursuit of a novel gene(s) that would be unique to the anergy phenotype. Several putative “anergy factors” have been suggested. In this review, we provide an overview of the anergy phenotype and proposed anergy-related genes. To date, no single gene has been described that would completely fulfill the criteria of an “anergy factor”. We review work from our laboratory describing a novel gene that we have termed Gene Related to Anergy In Lymphocytes (GRAIL) that is upregulated in T cells anergized in vitro and in vivo and, following transduction into T cells, reiterates the anergy phenotype.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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